Indication of Alben DS 400 mg
For both single and combined hookworm infestations, Alben DS 400 mg is recommended for Hookworm (Ancylostoma, Necator), Roundworm (Ascaris), Threadworm (Enterobius), Whipworm (Trichuris), Strongyloides, Tapeworm, Opisthorchi, Hydatid.
Pharmacology of Alben DS 400 mg
A broad spectrum anthelmintic is albendazole. The compound albendazole possesses larvicidal, ovicidal, and vermicidal properties. It is believed that the medication works as an anthelmintic by preventing the vulnerable helminths from absorbing glucose, which lowers their energy levels until they are insufficient for survival. The parasite then follows immobilization. Albendazole and its metabolites bind to parasite tubulin and subsequently impede its polymerization, which could explain these occurrences, even though the medicine also binds to human tubulin. The liver is most likely where albendazole undergoes substantial metabolism. Albendazole undergoes a quick and extensive first-pass metabolism while being poorly absorbed from the gastrointestinal system. Albendazole sulphoxide, the primary metabolite, has a plasma half-life of roughly 8.5 hours and anthelmintic action. It and other metabolites are eliminated through the urine.
Therapeutic Class of Alben DS 400 mg
Anthelmintic
Dosage and Administration of Alben DS 400 mg
In cases of Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, and Necator americanus, adults and children over the age of two should take 400 mg (1 tablet or 10 ml suspension) as a single dosage. For three days straight, 400 mg (1 tablet or 10 ml suspension) should be administered daily in cases of strongyloidiasis or taeniasis. A second session of treatment is recommended if, after three weeks, the patient is still not well. For children aged 1-2 years, a single dosage of 200 mg (5 ml suspension) is advised. Youngsters under a year old: Not advised. In cases of Hydatid illness (Echinococcosis), patients over 60 kg should take 400 mg of Alben DS 400 mg orally with meals twice daily for 28 days.
For patients under 60 kg, a maximum daily dose of 800 mg is administered in two divided doses at a rate of 15 mg/kg body weight. After 14 days without therapy, the 28-day course may be repeated for a total of three treatment cycles for cystic echinococcosis. Therapy for alveolar echinococcosis may need months or even years of cycles consisting of 28 days of treatment followed by 14 days off. 400 mg (1 pill or 10 ml suspension) once daily for five days is the recommended dosage for giardiasis.
Contraindications of Alben DS 400 mg
Neonatal: It is not customary to administer Alben DS 400 mg to newborns. Children: There is no reason to lower the dosage for children generally; however, in children under 10 kg, a reduction from 400 mg to 200 mg may be required.The woman who is pregnant: Women who are suspected of being pregnant should not use Alben DS 400 mg. There is no information about placental transfer at this time. Concurrent disease: No proof of changing the dosage in renal, hepatic, or cardiac failure cases is warranted.
Side Effects of Alben DS 400mg
There have been reports of rash, fever, blood disorders including leucopenia and pancytopenia, anaphylactic shock in the event of cyst leaking, convulsion and meningism in cerebral disease, and digestive disturbances, headache, dizziness, changes in liver enzymes, and infrequently reversible baldness.
Interaction of Alben DS 400 mg
There haven't been any documented pharmacodynamic or pharmacokinetic interactions with Alben DS 400 mg.
Precautions & Warnings of Alben DS 400 mg
Before beginning therapy, get blood counts and liver function tests, have them done twice during each cycle, breastfeed, and rule out pregnancy. Alben DS 400 mg should only be used to treat echinococcosis under continuous medical supervision and regularly monitoring serum-transaminase concentrations and leucocyte and platelet counts.
Storage Conditions of Alben DS 400 mg
Store away from heat and light in a dry area. Keep out of children's reach.
Pregnancy & Lactation of Alben DS 400 mg
Albendazole's US FDA pregnancy category is C. Therefore, unless the potential advantages to one another outweigh the possible risks to the fetus, Alben ds 400 mg should be avoided throughout pregnancy and lactation.
